Salmonella - at home in the host cell.

Salmonella - at home in the host cell.

Blog Article

The Gram-negative bacterium Salmonella enterica has developed an array of sophisticated Cables tools to manipulate the host cell and establish an intracellular niche, for successful propagation as a facultative intracellular pathogen.While Salmonella exerts diverse effects on its host cell, only the cell biology of the classic trigger-mediated invasion process and the subsequent development of the Salmonella-containing vacuole have been investigated extensively.These processes are dependent on cohorts of effector proteins translocated into host cells by two type III secretion systems (T3SS), although T3SS-independent mechanisms of entry may be important for invasion of certain host cell-types.

Recent studies into the intracellular lifestyle of Salmonella have provided new insights into the mechanisms used by this pathogen to modulate its intracellular environment.Here we discuss current knowledge of Salmonella-host interactions including invasion Acrylic Keychain and establishment of an intracellular niche within the host.